Enzyme Engineering and Drug Discovery

Enzymes are the substances which are used to speed up the reaction, and enzyme production is the one of the main sector of industrial biotechnology. Due to the advancements in biotechnology, these are extracted from specific microorganisms by the process of fermentation, provided with favorable conditions. Microbial enzymes have gained interest for their widespread application in industries and medicines.

Drug discovery is the process through which potential new medicines are recognized and comprises an extensive range of scientific disciplines, including biology, chemistry and pharmacology. The integration of pharmacodynamics and pharmacokinetic parameters in non-clinical pharmacology studies is a key characteristic in drug discovery for efficacy and safety assessment, in the particular for the translation from the non-clinical to  clinical field and process of drug discovery include  the identification of candidates, synthesis, characterization, screening, and assays for therapeutic efficacy where as modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity, efficacy/potency, metabolic stability, and oral bioavailability. The "final product" of drug discovery is a patent on the potential drug.

 

  • Cell-based systems
  • Bacterial systems
  • Filamentous fungi
  • Non-lytic insect cell expression
  • Application in food industries
  • Application in pharmaceutical industries
  • Application in leather industries
  • Application in paper industries

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